Sunday, June 1, 2025

Polaris of Enlightenment

Australia approves psychedelics for medical use

Published 5 July 2023
– By Editorial Staff
Psilocybe semilanceata, or liberty cap, grows in many parts of the world, including northern Europe.

As of July 1, psychiatrists in Australia will be able to prescribe MDMA and psilocybin, which are found in psychedelic mushrooms. This makes Australia the first country to formally approve these drugs for medical treatment.

Both MDMA and psilocybin are classified as narcotics in Sweden and many other countries. Now, however, patients in Australia can be prescribed the substances as medicine for mental health problems, reports The Guardian. The country is the first in the world to approve the substances for clinical treatment.

Psilocybin is already formally legal in a few countries, including Brazil, Nepal and the Netherlands, but it is not used in medical or psychiatric settings. MDMA is currently under investigation for medical use in the United States, and is permitted for limited personal use in the province of British Columbia, Canada. Psychedelic substances, including psilocybin and MDMA, can exceptionally be distributed in Canada through a special application to the Ministry of Health. However, Australia will be the first country to allow the substances to be prescribed by doctors for treatment.

MDMA is primarily used to treat post-traumatic stress disorder (PTSD), while psilocybin is primarily used to treat depression.

Mixed views on the decision

Psychology professor Susan Rossell, who is currently conducting a major study in Australia on depression and psilocybin, is “cautious” about the new legislation, saying that the medical studies are not yet comprehensive enough.

– We’ve got no data on long-term outcomes at all, so that worries me a lot, says Rossel in a comment to The Guardian.

But Dr. Mike Musker, a mental health researcher at the University of South Australia, calls it a success and “one of the biggest evolutions in psychiatry in the last 70 years”.

The role of MDMA in psychiatry has also been discussed in Sweden, including at a 2019 conference on the topic organized by the Network on Psychedelic Science, which was attended by several of the world’s leading researchers in the field. A so-called phase 3 trial at the University of California, published in Nature Medicine in 2021, for the treatment of patients with severe PTSD, including war veterans, has also prompted Gita Rajan, a doctor and PhD student at Karolinska Institutet, to plan a pilot study in Sweden. This study will investigate the effects of MDMA on her patient population of people suffering from PTSD after severe sexual violence.

MDMA increases the possibilities for treatment more than any other drug available today, Rajan said in a commentary on the study to taxpayer-funded SVT.

The Facts: MDMA and Psilocybin

Psilocybin is a substance found in mushrooms of the genus psilocybin that induces so-called psychedelic states of consciousness. Thoughts, feelings, and perceptions are greatly altered in a way that is often described as a spiritual experience. The substance belongs to the class of enteogens, traditional natural medicines with hallucinogenic properties used in psychotherapeutic and shamanistic contexts. In recent years, it has received widespread attention in the West for its potential healing effects, with warnings that careless use is very risky and can cause both panic attacks and psychotic episodes.

MDMA (methylenedioxymethamphetamine) is a central stimulant introduced in the early 1900s and originally used as a weight-loss drug. It is the psychoactive substance in the party drug known as "ecstasy," although in practice it is often a mixture of several different substances. MDMA affects the nervous system and, like psilocybin, can induce psychedelic states of consciousness. It is classified as an empathogen, which affects the state of mind rather than perception. It releases serotonin in the brain, usually causing intense euphoria and alertness, but can also cause hyperactivity, anxiety, and decreased self-control. Like psilocybin, it has attracted attention for its potentially medicinal effects, while also warning that careless use is very dangerous. Among other things, it can cause neurotoxic damage with symptoms such as persistent anxiety, fatigue, difficulty sleeping, and depression.

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Use of obesity drugs surges in Finland

Published 27 May 2025
– By Editorial Staff
Sales of obesity medication have skyrocketed in Finland in just a few years.

The use of obesity medication increased significantly in Finland last year – many more Finns were treated for obesity compared to 2023. At the same time, opinions are divided on the effectiveness of the treatment.

A total of 75,000 Finns used medicines for weight loss or obesity treatment in 2024. This is an increase of 20% compared to 2023, according to the Social Insurance Institution of Finland (Kela). In five years, the number of users has increased more than elevenfold.

Semaglutide, sold under brands such as Ozempic and Wegovy, is the most popular. Originally designed as a drug for the treatment of type 2 diabetes, this type of medicine is not reimbursed if it is used for obesity alone. This means that Finns have to foot the bill themselves, which can be over €260 each month.

It is also unclear how effective this type of weight loss medication really is, but Pia Pajunen, an expert physician at Kela, says it is not a quick fix for losing weight.

If you stop using the obesity medication, the weight often starts to increase again quickly. It’s important that both doctors and patients are aware that research shows these medications generally need to be used long-term, she says in a press release.

Good fitness may prevent dementia

Published 27 May 2025
– By Editorial Staff

People at risk of dementia can reduce their risk by improving their fitness, according to a study from Karolinska Institutet. The study shows that the risk can be reduced by up to 35%.

In the study, published in the British Journal of Sports Medicine, researchers used data from 61,214 dementia-free people, drawn from the UK Biobank database. The participants, who were aged between 39 and 70, were followed over a period of 12 years.

On enrollment, participants completed a six-minute cycle test to measure fitness, and neurological tests were done to estimate their cognitive function. The researchers also examined genetic predisposition to dementia.

During the 12-year follow-up period, a total of 553 people were diagnosed with dementia, representing 0.9%.

The results show that better fitness is linked to reduced dementia risk and improved cognitive function. According to Weili Xu, Professor of Geriatric Epidemiology in the Department of Neurobiology, Care Sciences and Society, good fitness can reduce the risk of all forms of dementia by up to 35%.

– Our findings suggest that maintaining good fitness may be a strategy for preventing dementia, even among people with high genetic susceptibility, she says in a press release.

The researchers also emphasize that this is an observational study, so it is not possible to determine cause and effect. The number of dementia cases may also have been underestimated, they add, as UK Biobank participants are generally healthier than the general population.

Ultra-processed food may increase the risk of cardiovascular disease

Published 21 May 2025
– By Editorial Staff

Extra-processed foods and sugar-sweetened beverages are linked to a particularly increased risk of premature death from cardiovascular disease, according to a study from Lund University.

Ultra-processed food is food that has undergone extensive processing and contains a high proportion of added chemicals compared to “regular” processed food. This type of food is often cheap, heavily marketed and has become an increasingly important part of the Western diet in recent years.

In the study, published in Clinical Nutrition, researchers followed 27 670 participants from the Malmö Diet Cancer Study over 23 years, with funding from the Swedish Heart and Lung Foundation.

The results show that a high intake of highly processed foods and sugar-sweetened beverages is linked to an increased risk of premature death, death from cardiovascular disease and death from respiratory disease. There is an increased risk for women.

– Over-processed foods are often rich in salt, fat and added sugars, but often poor in fiber, vitamins and nutrients. Limiting intake can reduce the risk of premature death, says Emily Sonestedt, associate professor at Lund University and lead researcher of the study, in a press release.

Ultra-processed food is markedly different from what humans have been eating for thousands of years, but the long-term effects on health have yet to be studied in depth. However, links between this type of food have previously been made to depression and type 2 diabetes. At the same time, the researchers point out that more studies are needed on the subject.

–  More research is needed to better understand how ultra-processed food affects the body. In future studies, we will be able to analyze current dietary data in the Swedish population and learn more about the relationship with cardiovascular disease, says Kristina Sparreljung, Secretary General of the Swedish Heart-Lung Foundation.

Sauerkraut may help your stomach

Published 11 May 2025
– By Editorial Staff

Sauerkraut may protect the intestinal lining from inflammation, according to an American study. During fermentation, the nutritional content of cabbage changes – including an increase in levels of lactic acid, amino acids, and other beneficial substances that are formed during the breakdown and can promote gut health.

Fermentation is a natural process where microorganisms like lactic acid bacteria and yeast break down sugars in food. This often results in the conversion of sugar into lactic acid or alcohol. The process not only helps preserve the food – it also produces probiotics, meaning live bacteria that are beneficial for the gut.

Fermented foods have been eaten for thousands of years around the world. For example, eating fermented vegetables makes the nutrients in the food easier for the body to absorb, and some studies show that vitamin levels can actually increase. There are also studies that suggest fermented foods can have positive effects on health, particularly for digestion and the immune system.

Sauerkraut better than raw cabbage

Researchers at the University of California Davis in the USA tested whether the nutrients in sauerkraut could help protect intestinal cells from inflammation-related damage. The study compared sauerkraut, raw cabbage, and the brine left over after the cabbage fermentation process.

The experiments were conducted on an artificial intestinal wall exposed to inflammation by adding so-called cytokines – which are known to damage the intestinal lining. These can be activated in the gut, for example, by consuming too much ultra-processed food or too much sugar or salt.

Fermentation increases beneficial substances

The results showed that sauerkraut can protect the intestinal lining from inflammation caused by cytokines. Raw cabbage and the brine, however, did not help protect the gut. It didn’t matter whether the sauerkraut was store-bought or homemade.

Chemical analyses show that fermentation changes the nutritional profile of cabbage and increases the amount of beneficial metabolites such as lactic acid, amino acids, and plant compounds, which in turn are linked to gut health. These changes may explain why fermented foods are often associated with digestive benefits.

– Some of the metabolites we find in the sauerkraut are the same kind of metabolites we’re finding to be made by the gut microbiome, so that gives us a little more confidence that this connection we found between the metabolites in sauerkraut and good gut health makes sense, says Professor Maria Marco in a press release.

The researchers have found hundreds of different metabolites that are formed during fermentation and that they are now working to determine which ones play the biggest role in supporting long-term gut health. The next step in the research is to conduct studies in humans to see if the gut-protective metabolites found in sauerkraut can have the same positive effects when included in the daily diet, as was shown in the lab.

A little bit of sauerkraut could go a long way, she says. We should be thinking about including these fermented foods in our regular diets and not just as a side on our hot dogs.

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