Saturday, April 19, 2025

Polaris of Enlightenment

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British Opal gets her hearing back with gene therapy

Published 13 May 2024
– By Editorial Staff
Opal with her big sister Nora.

18-month-old Opal Sandy has regained her hearing after a unique ‘gene therapy’ operation. The girl is the first in the world to undergo the procedure.

Opal Sandy was born deaf as a result of auditory neuropathy, a condition that disrupts nerve impulses from the inner ear to the brain and can be caused by a faulty gene. Opal’s five-year-old sister, Nora, has the same type of deafness, but is helped by a cochlear implant that sends electrical signals to the auditory nerve, bypassing the defective parts of the ear.

It was a big decision for parents Jo and James, from Owfordshire, to have their daughter operated on.

– It was really scary, but I think we’d been given this unique opportunity, her mother said in an interview with the British state broadcaster BBC.

During the operation, the girl was given an infusion containing a copy of her missing gene. After the 16-minute operation, the girl was able to hear.

– I couldn’t really believe it, Opal’s mother Jo Sandy told The Guardian. It was … bonkers.

The operation is the first of its kind and was performed at Addenbrooke’s Hospital, part of the Cambridge University Hospitals NHS Foundation Trust. Other deaf children are now being recruited for the operation and will be followed for five years.

Ear surgeon Professor Manohar Bance says these early results from the operation are “better than I hoped or expected”.

– We have results from [Opal] which are very spectacular – so close to normal hearing restoration. So we do hope it could be a potential cure, he says, adding:

– There’s been so much work, decades of work.

A second child recently underwent a similar operation at Cambridge University with good results.

It is now hoped that this type of gene therapy could be used for other types of deafness, as half of all hearing loss in children has a genetic cause. Today, most people, like Opal’s sister Nora, receive a cochlear implant, a device that needs to be replaced several times. But it is important to have the surgery as early as possible, before the age of three, when the brain is more adaptable.

Now that Opal’s hearing has been restored, her parents have other problems to deal with. Opal has a new hobby: banging cutlery on the table as hard as she can to make as much noise as possible.

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Painkillers linked to increased risk propensity

Published today 15:43
– By Editorial Staff
If large groups have an impaired perception of risk, this can have significant societal consequences.

Paracetamol can affect how we perceive risk, according to a US study. Students given painkillers before experiments were found to take greater risks than those given a placebo – something the researchers say may also have societal implications.

Paracetamol is an over-the-counter medication commonly taken for pain and fever and is available in the form of several different brands such as Alvedon, Orifarm and Apofri.

In the study, which was published in Social Cognitive and Affective Neuroscience in 2020, participants were asked to perform various experiments and then assessed based on their risk-taking. Over 500 university students took part in the experiments, with half of the group receiving a single dose of 1000 milligrams of acetaminophen before the experiments, and the rest receiving a placebo.

In one of the experiments, participants had to inflate balloons via a computer game, with each individual pump providing pretend money. The point was not to blow up the balloon with too much air as all the money earned would be lost. The results showed that the students taking paracetamol engaged in significantly more risk-taking during the exercise, compared to the more cautious placebo group.

Overall, those taking paracetamol inflated, and burst, their balloons more than the control group.

“Less negative emotions”

Researcher Baldwin Way from Ohio State University, who is behind the study, believes that this may have to do with the fact that paracetamol has a certain anxiolytic effect.

If you’re risk-averse, you may pump a few times and then decide to cash out because you don’t want the balloon to burst and lose your money, Way says, adding:

But for those who are on acetaminophen, as the balloon gets bigger, we believe they have less anxiety and less negative emotion about how big the balloon is getting and the possibility of it bursting.

The balloon experiment was repeated twice, with similar results. Furthermore, during the experiments, participants were asked to complete questionnaires in which they had to assess risk levels around hypothetical scenarios. For example, betting a day’s income on a sporting event, bungee jumping off a high bridge or driving a car without a seatbelt.

“Significant effects on society”

Those who had taken paracetamol were clearly more comfortable with, for example, the idea of driving without a seatbelt compared to the placebo group.

Way says the study suggests that the substance “seems to make people feel less negative emotion when they consider risky activities”, which he says could have implications for society.

With nearly 25 per cent of the population in the US taking acetaminophen each week, reduced risk perceptions and increased risk-taking could have important effects on society, he says.

Comment: An entire world was injected – but the silence about the long-term side effects is total

The criticized covid vaccinations

Early warnings about the long-term risks of experimental mRNA vaccines were dismissed as conspiracy theorists and quacks. In hindsight, most evidence suggests that their fears were justified and new findings indicate that the vaccines can cause long-term changes in the genetic structure of the body.

Published yesterday 11:23
– By Jenny Piper
A German study shows that the COVID-19 vaccine can affect the genetic structure of the body, triggering inflammatory reactions, autoimmune conditions and in some cases cancer.
{ $opinionDisclaimer }

Even at the beginning of the mass vaccination hysteria, I often wrote about the risks of taking the mRNA vaccine shots because the long-term side effects of this fast-acting so-called vaccine are unknown and will only become apparent in a few years.

Whistleblowers from within the pharmaceutical industry had also flagged this very aspect early on – that it is designed to seek out possible weaknesses in people’s immune systems, where it accelerates the development of cancer, autoimmune diseases and cardiovascular diseases. This was of course dismissed as quackery and conspiracy theories, which is why the vast majority of the population rolled up their sleeves at least twice.

Now, a new peer-reviewed study from Germany on mRNA-based Covid-19 vaccines shows that they can cause long-term changes in the body’s genetic structure – changes that in turn can trigger inflammatory reactions, autoimmune conditions and, in some cases, cancer.

19 researchers at leading German institutions conducted the study, which was published in Molecular Systems Biology at the end of March. It shows a possible link between mRNA vaccines and epigenetic changes in immune cells, specifically linked to a protein called histone 3 lysine 27 acetylation (H3K27ac), a protein that has been associated with leukemia and brain tumors.

Histones act as “coils” around which the DNA strand is wound, helping to give DNA its three-dimensional structure. Changes in these proteins affect how genes are expressed. The looser the histones are, the more actively the DNA is transcribed, which in some cases can stimulate tumor growth.

The researchers analyzed how the chromosomes of macrophages (a type of white blood cell) are affected by mRNA vaccination. The results showed persistent epigenetic changes in these cells, which could explain some post-vaccination inflammatory diseases.

Histone modifications – where the structure of DNA is altered without changing the DNA code itself – can play an important role in how genes are expressed. In this case, the researchers found a change in H3K27ac that persisted for months after vaccination, raising concerns about possible long-term effects on the immune system.

According to the researchers, changes in H3K27ac can be linked to several cancers, including gliomas (brain tumors) and leukemia. Other studies, including those from China and Poland, have also linked this particular type of histone modification to cancer.

Several scientists and experts have commented on the study.

Alex Berenson, an independent journalist, says the results show how mRNA vaccines can affect chromosomes in a way that is associated with brain tumors and leukemia.

Nicolas Hulscher, an epidemiologist, says the study adds to a growing body of evidence that mRNA vaccines can disrupt the balance of the immune system and lead to chronic inflammatory conditions.

Jessica Rose, Ph.D., immunologist and biochemist, points out that it is already known that repeated injections cause immunological changes and that these changes can reach stem cells and affect the long-term functioning of the immune system.

Other studies have shown that the levels of synthetic DNA in some vaccine doses (from Pfizer and Moderna) have been well above permissible limits – in some cases up to 470 times higher than regulatory guidelines allow.

The fact that so-called turbo cancer has risen sharply in recent years is hardly a coincidence. Unfortunately, I think we have only seen the beginning of this – and the Swedish establishment has put a lid on the whole thing.

 

Jenny Piper

All Jenny Piper's articles can be found on her blog.

Researchers create unique brain map using mouse and movie clips

Published 15 April 2025
– By Editorial Staff
The researchers believe that the technology developed could be useful for identifying disorders in the brain.

Using a mouse to watch various movie clips, including The Matrix, scientists have created the largest ever functional 3D map of part of a mammalian brain. The high-resolution map contains more than 200 000 brain cells.

Thoughts, emotions, speech and movements are controlled by neurons in the brain that send signals via axons, dendrites and synapses. But how networks of neurons interact – and how disruptions in these connections can contribute to diseases such as Alzheimer’s or autism – is not yet fully understood.

– You can make a thousand hypotheses about how brain cells might do their job, but you can’t test those hypotheses unless you know perhaps the most fundamental thing – how are those cells wired together, Clay Reid, a researcher at the Allen Institute, tells CBC.

A new project, presented in a total of eight studies by a global team of more than 150 scientists, aims to take brain research a step further by mapping parts of a mouse brain. For two hours, the mouse was shown various clips from movies, including The Matrix, and then researchers were able to map cells in one cubic millimeter of the mouse’s brain tissue, creating a high-resolution 3D map. It contains over 200 000 brain cells, of which about 82 000 are neurons.

The previous most detailed map of a human brain contains 16 000 neurons.

Like looking at the “stars at night”

The new map also captures the activity of tens of thousands of neurons that fire signals and interact with each other to process visual information. The results “are really stunningly beautiful”, says Forrest Collman, a neuroscientist at the Allen Institute, who co-authored the study.

– Looking at it really gives you an awe about the sense of complexity in the brain that is very much akin to looking up at the stars at night, he tells Nature.

The researchers call the project a new fundamental step in brain research and believe that the technique developed could be useful for identifying disorders in the brain. The next step is to map an entire mouse brain.

The technologies developed by this project will give us our first chance to really identify some kind of abnormal pattern of connectivity that gives rise to a disorder, says Sebastian Seung, a Princeton neuroscientist and computer scientist, one of the study’s lead researchers.

Study: Deaths after covid vaccine were in most cases due to the shot

The criticized covid vaccinations

Published 12 April 2025
– By Editorial Staff
Cardiologist Peter McCullough is one of the researchers behind the study.

In a new study, doctors infer covid vaccine as a direct or contributing cause in three out of four cases of 325 autopsies reviewed where individuals took the injections before death.

The researchers reviewed a total of 44 scientific articles with a total of 325 autopsy cases found of people who died after being injected with COVID-19 vaccine. To find the articles, search terms such as “COVID-19 Vaccine”, “SARS-CoV-2 Vaccine”, “COVID Vaccination”, “Post-mortem” and “Autopsy” were used.

In each case, three independent doctors reviewed the autopsy results to assess whether the COVID vaccine could be the direct cause or a contributing cause of death.

Among others, former cardiologist Peter McCullough is one of the researchers behind the study. McCullough has been a very strong critic of the covid policy including the mass vaccination campaign, and strongly urged, among other things, that people under the age of 50 and those who had the infection did not need to inject themselves with the covid vaccines.

Myocarditis and sudden cardiac death

The study, published in the peer-reviewed journal Public Health Policy and the Law, shows that in 74% of cases, at least two out of three physicians considered the COVID-19 vaccination to be a direct or contributing cause of death.

The most common causes of death were sudden cardiac death, pulmonary embolism, myocardial infarction, VITT (vaccine-induced thrombosis), myocarditis, inflammatory syndrome and cerebral hemorrhage. Most deaths studied occurred within a week of vaccination.

Commenting on the study, Swedish physician Nils Littorin says the results are striking.

 

Translation of above tweet: “This is BIG! New medical study of autopsied deaths after COVID-19 vaccine shows that 74% of 326 cases were caused by the vaccine.
The heart and vascular system were the most common organ systems to be injured, followed by hematological and respiratory.” 

Call for in-depth studies

According to the authors, the patterns revealed by the study suggest a causal link between COVID-19 vaccination and increased mortality, while calling for much more extensive and in-depth studies in this area.

Further urgent investigation is required for the purpose of clarifying our findings”, the researchers write.

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