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https://nordictimes.com/science/adhd-medication-increases-risk-of-psychosis/

Science

ADHD medication increases risk of psychosis

Published 13 October 2024
– By Editorial Staff
Editorial Staff
editorial@nordictimes.com

Adults taking high doses of medication for ADHD are five times more likely to suffer from psychosis or manic episodes, according to a US study from McLean Hospital.

The study, published in the American Journal of Psychiatry, is based on data from patients hospitalized for psychosis or mania between 2005 and 2019. The patients, who were between 16 and 35 years old, had no previous history of these conditions. The researchers also used a control group of patients who had been hospitalized for other mental health conditions, such as anxiety or depression, but not psychosis or mania.

The patients were admitted through the emergency department of Mass General Brigham Hospital in Massachusetts.

The study found that people who had used amphetamine-based drugs in the past month were at a significantly higher risk of developing psychosis or mania compared to those who had not taken such drugs. The risk was over two times higher in these individuals. In total, the researchers found that 63% of all psychosis or mania cases among amphetamine users could have been avoided if the drug had not been taken.

Furthermore, they found that increased doses of amphetamine-based drugs were linked to a higher risk of psychosis or mania. Patients taking 30 milligrams or more were five times more likely to develop these conditions, according to the researchers.

Authors urge caution

The researchers estimated that up to 81% of psychosis or mania could have been avoided by reducing the dose of the drug.

However, the study found no increased risk of psychosis or mania in patients using methylphenidate-based drugs, such as Ritalin, compared to those not using such medications.

The researchers urge doctors to be more cautious when prescribing these drugs, especially to patients with risk factors for psychotic or manic episodes.

– Stimulant medications don’t have an upper dose limit on their labels, and our results show that it is clear that dose is a factor in psychosis risk and should be a chief consideration when prescribing stimulants, said the study’s lead author Lauren Moran, who researches pharmacoepidemiology at McLean Hospital, in a press release.

Editorial Staff
editorial@nordictimes.com

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https://nordictimes.com/science/an-entire-world-was-injected-but-the-silence-about-the-long-term-side-effects-is-total/

Science

Comment: An entire world was injected – but the silence about the long-term side effects is total

The criticized covid vaccinations

Jenny Piper

Early warnings about the long-term risks of experimental mRNA vaccines were dismissed as conspiracy theorists and quacks. In hindsight, most evidence suggests that their fears were justified and new findings indicate that the vaccines can cause long-term changes in the genetic structure of the body.

Published today 11:23
– By Jenny Piper
A German study shows that the COVID-19 vaccine can affect the genetic structure of the body, triggering inflammatory reactions, autoimmune conditions and in some cases cancer.
{ $opinionDisclaimer }

Even at the beginning of the mass vaccination hysteria, I often wrote about the risks of taking the mRNA vaccine shots because the long-term side effects of this fast-acting so-called vaccine are unknown and will only become apparent in a few years.

Whistleblowers from within the pharmaceutical industry had also flagged this very aspect early on – that it is designed to seek out possible weaknesses in people’s immune systems, where it accelerates the development of cancer, autoimmune diseases and cardiovascular diseases. This was of course dismissed as quackery and conspiracy theories, which is why the vast majority of the population rolled up their sleeves at least twice.

Now, a new peer-reviewed study from Germany on mRNA-based Covid-19 vaccines shows that they can cause long-term changes in the body’s genetic structure – changes that in turn can trigger inflammatory reactions, autoimmune conditions and, in some cases, cancer.

19 researchers at leading German institutions conducted the study, which was published in Molecular Systems Biology at the end of March. It shows a possible link between mRNA vaccines and epigenetic changes in immune cells, specifically linked to a protein called histone 3 lysine 27 acetylation (H3K27ac), a protein that has been associated with leukemia and brain tumors.

Histones act as “coils” around which the DNA strand is wound, helping to give DNA its three-dimensional structure. Changes in these proteins affect how genes are expressed. The looser the histones are, the more actively the DNA is transcribed, which in some cases can stimulate tumor growth.

The researchers analyzed how the chromosomes of macrophages (a type of white blood cell) are affected by mRNA vaccination. The results showed persistent epigenetic changes in these cells, which could explain some post-vaccination inflammatory diseases.

Histone modifications – where the structure of DNA is altered without changing the DNA code itself – can play an important role in how genes are expressed. In this case, the researchers found a change in H3K27ac that persisted for months after vaccination, raising concerns about possible long-term effects on the immune system.

According to the researchers, changes in H3K27ac can be linked to several cancers, including gliomas (brain tumors) and leukemia. Other studies, including those from China and Poland, have also linked this particular type of histone modification to cancer.

Several scientists and experts have commented on the study.

Alex Berenson, an independent journalist, says the results show how mRNA vaccines can affect chromosomes in a way that is associated with brain tumors and leukemia.

Nicolas Hulscher, an epidemiologist, says the study adds to a growing body of evidence that mRNA vaccines can disrupt the balance of the immune system and lead to chronic inflammatory conditions.

Jessica Rose, Ph.D., immunologist and biochemist, points out that it is already known that repeated injections cause immunological changes and that these changes can reach stem cells and affect the long-term functioning of the immune system.

Other studies have shown that the levels of synthetic DNA in some vaccine doses (from Pfizer and Moderna) have been well above permissible limits – in some cases up to 470 times higher than regulatory guidelines allow.

The fact that so-called turbo cancer has risen sharply in recent years is hardly a coincidence. Unfortunately, I think we have only seen the beginning of this – and the Swedish establishment has put a lid on the whole thing.

 

Jenny Piper

All Jenny Piper's articles can be found on her blog.

https://nordictimes.com/science/researchers-create-unique-brain-map-using-mouse-and-movie-clips/

Science

Researchers create unique brain map using mouse and movie clips

Published 15 April 2025
– By Editorial Staff
The researchers believe that the technology developed could be useful for identifying disorders in the brain.
Editorial Staff
editorial@nordictimes.com

Using a mouse to watch various movie clips, including The Matrix, scientists have created the largest ever functional 3D map of part of a mammalian brain. The high-resolution map contains more than 200 000 brain cells.

Thoughts, emotions, speech and movements are controlled by neurons in the brain that send signals via axons, dendrites and synapses. But how networks of neurons interact – and how disruptions in these connections can contribute to diseases such as Alzheimer’s or autism – is not yet fully understood.

– You can make a thousand hypotheses about how brain cells might do their job, but you can’t test those hypotheses unless you know perhaps the most fundamental thing – how are those cells wired together, Clay Reid, a researcher at the Allen Institute, tells CBC.

A new project, presented in a total of eight studies by a global team of more than 150 scientists, aims to take brain research a step further by mapping parts of a mouse brain. For two hours, the mouse was shown various clips from movies, including The Matrix, and then researchers were able to map cells in one cubic millimeter of the mouse’s brain tissue, creating a high-resolution 3D map. It contains over 200 000 brain cells, of which about 82 000 are neurons.

The previous most detailed map of a human brain contains 16 000 neurons.

Like looking at the “stars at night”

The new map also captures the activity of tens of thousands of neurons that fire signals and interact with each other to process visual information. The results “are really stunningly beautiful”, says Forrest Collman, a neuroscientist at the Allen Institute, who co-authored the study.

– Looking at it really gives you an awe about the sense of complexity in the brain that is very much akin to looking up at the stars at night, he tells Nature.

The researchers call the project a new fundamental step in brain research and believe that the technique developed could be useful for identifying disorders in the brain. The next step is to map an entire mouse brain.

– The technologies developed by this project will give us our first chance to really identify some kind of abnormal pattern of connectivity that gives rise to a disorder, says Sebastian Seung, a Princeton neuroscientist and computer scientist, one of the study’s lead researchers.

Editorial Staff
editorial@nordictimes.com

https://nordictimes.com/science/study-deaths-after-covid-vaccine-were-in-most-cases-due-to-the-shot/

Science

Study: Deaths after covid vaccine were in most cases due to the shot

The criticized covid vaccinations

Published 12 April 2025
– By Editorial Staff
Cardiologist Peter McCullough is one of the researchers behind the study.
Editorial Staff
editorial@nordictimes.com

In a new study, doctors infer covid vaccine as a direct or contributing cause in three out of four cases of 325 autopsies reviewed where individuals took the injections before death.

The researchers reviewed a total of 44 scientific articles with a total of 325 autopsy cases found of people who died after being injected with COVID-19 vaccine. To find the articles, search terms such as “COVID-19 Vaccine”, “SARS-CoV-2 Vaccine”, “COVID Vaccination”, “Post-mortem” and “Autopsy” were used.

In each case, three independent doctors reviewed the autopsy results to assess whether the COVID vaccine could be the direct cause or a contributing cause of death.

Among others, former cardiologist Peter McCullough is one of the researchers behind the study. McCullough has been a very strong critic of the covid policy including the mass vaccination campaign, and strongly urged, among other things, that people under the age of 50 and those who had the infection did not need to inject themselves with the covid vaccines.

Myocarditis and sudden cardiac death

The study, published in the peer-reviewed journal Public Health Policy and the Law, shows that in 74% of cases, at least two out of three physicians considered the COVID-19 vaccination to be a direct or contributing cause of death.

The most common causes of death were sudden cardiac death, pulmonary embolism, myocardial infarction, VITT (vaccine-induced thrombosis), myocarditis, inflammatory syndrome and cerebral hemorrhage. Most deaths studied occurred within a week of vaccination.

Commenting on the study, Swedish physician Nils Littorin says the results are striking.

 

Translation of above tweet: “This is BIG! New medical study of autopsied deaths after COVID-19 vaccine shows that 74% of 326 cases were caused by the vaccine.
The heart and vascular system were the most common organ systems to be injured, followed by hematological and respiratory.” 

Call for in-depth studies

According to the authors, the patterns revealed by the study suggest a causal link between COVID-19 vaccination and increased mortality, while calling for much more extensive and in-depth studies in this area.

“Further urgent investigation is required for the purpose of clarifying our findings”, the researchers write.

Editorial Staff
editorial@nordictimes.com

https://nordictimes.com/science/game-of-thrones-wolf-recreated/

Science

Game of Thrones wolf recreated

Biodiversity

Published 9 April 2025
– By Editorial Staff
Today, the three puppies live in a secret location, surrounded by fences and monitored by security staff, drones and cameras.
Editorial Staff
editorial@nordictimes.com

Three pups of the giant wolf, also known as the dire wolf, have now been re-created by scientists in Texas. It is the first successful case in the world of so-called “de-extinction” – the revival of a previously extinct animal.

The Aenocyon species went extinct about 12 500 years ago and lived in North America. It was larger than its living relative the wolf, growing to around 1.5 meters in height and weighing between 50 and 80 kilograms. It also had thicker fur and a wider jaw than our modern-day wolf.

Researchers at the biotech company Colossal Bioscience have extracted DNA from fossils of the extinct giant wolf and examined them to determine genetic characteristics such as color, fur and size. The information was then used to modify cells of the modern-day relative, the gray wolf. In total, genetic modifications have been made in 14 different genes. Healthy developed embryos were then transferred to domestic dogs, which were large mixed-breed dogs, which then served as surrogate mothers.

– Our team took DNA from a 13,000 year old tooth and a 72,000 year old skull and made healthy dire wolf puppies, said Ben Lamm, Colossal’s co-founder and CEO, according to CNN.

On October 1, 2024, two male pups were born, and in January of this year, a female was also born.

Game of Thrones author invests

The giant wolf, known as the dire wolf, has made a strong mark on popular culture – not least in books, movies and TV shows. It is best known from the fantasy series Game of Thrones, where the Stark family has a dire wolf as their pet and weapon symbol.

In fact, the author of the book series, George R R Martin, is an investor in the company and the genetically modified wolves. He is also a “cultural advisor” to the company, which has also issued a press release on the cultural influence of the species. The books were also made into a popular TV series by HBO.

The males are named Romulus and Remus, while the female pup is named Khaleesi, which is a title given to the character Daenerys in the book series – who is not a member of the Stark family, but of the Targaryens, who have a dragon on their sigil.

Not a “dire wolf”

Although the scientists behind the genetically modified puppies claim that they are “de-extinction”, other researchers point out that this is not quite the case. The similarities are mainly in appearance, not in the DNA itself.

– This is a grey wolf with an edited genome, not a dire wolf, genome scientist Emily Roycroft told ABC. The genetic edits may have given these wolves a lighter coat to look reminiscent of a dire wolf – but what makes a species is more than just skin deep.

The biotech company emphasizes that the goal is not to recreate species with exact genetic identity, but to create so-called “functional copies”. The technology behind the giant wolf is also hoped to be used to help endangered animals.

– Our goal with de-extinction is always create functional copies of these extinct species. We were focusing on identifying variants that we knew would lead to one of these key traits, says Beth Shapiro, Colossal’s chief scientific officer.

Secret location

Today, the three pups live in a secret location with a 2,000-hectare area with a three-meter-high fence that is constantly monitored by security personnel, drones and even cameras. The pups are used to humans, but not tame, and are still in a juvenile phase.

– We’re still seeing a lot of juvenile behaviors.  We haven’t seen them really fully express all of their behavior, said Matt James, Colossal’s animal manager. They’re an amazing opportunity for us to learn tons and tons about de-extinction, about cloning, about genetic editing and all the effects after that.

Colossol is also working towards reviving the mammoth, dodo and Tasmanian tiger.

Editorial Staff
editorial@nordictimes.com

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