Saturday, May 31, 2025

Polaris of Enlightenment

Ayahuasca study gives hope to the depressed

Published 9 July 2022
– By Editorial Staff
Ayahuasca vines in the Amazon rainforest.

A team of Brazilian researchers has performed the first randomized, placebo-controlled clinical trial on ayahuasca – a psychedelic drink made from plants from the Amazon. The results, published in the journal ‘Psychological Medicine’, suggest that ayahuasca may work against major depression.

Ayahuasca, a word derived from the indigenous language Quechua, means “vine of the spirits.” Indigenous peoples from the Amazon region of Brazil, Peru, Colombia and Ecuador have been using the drink for therapeutic and spiritual purposes for centuries, and probably much longer than that.

The medicinal drink consists of two plants. Banisteriopsis caapi, a vine that winds its way up treetops and across rivers, is boiled together with psychotria viridis, a shrub whose leaves contain the psychoactive molecule DMT. Since the early 1930s, it has been documented how Brazilian religions began to take shape around the use of ayahuasca as a sacrament. By the 1980s, ayahuasca rituals had spread to the rest of Brazil and to other parts of the world.

Ayahuasca did not become legal in Brazil for religious reasons until 1987, after the country’s federal medical authority recognized the fact that “religious group members” had experienced outstanding benefits from taking it. Some people who drank ayahuasca described it as finding peace with themselves.

In the study, conducted at the Federal University of Brazil in Rio Grande do Norte, researchers used 218 people with depression. 29 of them were selected because their depression could not be treated. No one had a history of psychotic disorders, such as schizophrenia – something that ayahuasca is reported to make worse.

The 29 people were randomly selected to receive a treatment session where they received either an ayahuasca drink or a placebo drink. The placebo drink was a brown drink that tasted bitter and sour, made from water, yeast, citric acid and caramel color. Zinc sulfate mimicked two well-known side effects of ayahuasca, namely nausea and vomiting.

The treatments were done in a hospital, but the room was designed as a quiet and comfortable living room. The strong effects of ayahuasca – which include dreamlike visions, vomiting and intense introspection – usually last for about 4 hours. During this period, participants listened to two different playlists, one with instrumental music and another with Portuguese songs.

The patients were supervised by two assistants who were there to support if anyone felt anxious during the intense, emotional psychic experience.

One day after treatment, a large improvement of 50 percent was observed in all patients, which included reduced anxiety and better mood. One week later, 64 percent of those who received ayahuasca felt that their depression had improved. 27 percent of the placebo group felt the same way.

The study supports previous research done in Brazil in 2015, where it was tested whether ayahuasca could work as an antidepressant drug. The study, which Dr. Jaime Hallak led at the University of São Paulo, also showed that as little as one session of ayahuasca had an antidepressant effect. All 17 participants reported that their depressive symptoms had decreased in the first hours after taking ayahuasca. The effect lasted 21 days. The study received a lot of attention from researchers, while the promising results were limited because there was no control group on placebo. Dr. Hallak and the other researchers at the University of São Paulo were involved also in this study.

In clinical trials on depression, up to 45 percent of patients taking placebo may report major benefits. The placebo effect of depression is so strong that some researchers have questioned whether antidepressant medication really works.

It should be added that the traditional view of ayahuasca emphasizes the importance of an experienced and knowledgeable supervisor needing to be present to support participants during a treatment session – what is popularly called a “shaman”. This is mainly in the light of the drink’s strong psychoactive properties and that the risk of serious side effects during careless use is otherwise stated to be significant.

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Use of obesity drugs surges in Finland

Published 27 May 2025
– By Editorial Staff
Sales of obesity medication have skyrocketed in Finland in just a few years.

The use of obesity medication increased significantly in Finland last year – many more Finns were treated for obesity compared to 2023. At the same time, opinions are divided on the effectiveness of the treatment.

A total of 75,000 Finns used medicines for weight loss or obesity treatment in 2024. This is an increase of 20% compared to 2023, according to the Social Insurance Institution of Finland (Kela). In five years, the number of users has increased more than elevenfold.

Semaglutide, sold under brands such as Ozempic and Wegovy, is the most popular. Originally designed as a drug for the treatment of type 2 diabetes, this type of medicine is not reimbursed if it is used for obesity alone. This means that Finns have to foot the bill themselves, which can be over €260 each month.

It is also unclear how effective this type of weight loss medication really is, but Pia Pajunen, an expert physician at Kela, says it is not a quick fix for losing weight.

If you stop using the obesity medication, the weight often starts to increase again quickly. It’s important that both doctors and patients are aware that research shows these medications generally need to be used long-term, she says in a press release.

Good fitness may prevent dementia

Published 27 May 2025
– By Editorial Staff

People at risk of dementia can reduce their risk by improving their fitness, according to a study from Karolinska Institutet. The study shows that the risk can be reduced by up to 35%.

In the study, published in the British Journal of Sports Medicine, researchers used data from 61,214 dementia-free people, drawn from the UK Biobank database. The participants, who were aged between 39 and 70, were followed over a period of 12 years.

On enrollment, participants completed a six-minute cycle test to measure fitness, and neurological tests were done to estimate their cognitive function. The researchers also examined genetic predisposition to dementia.

During the 12-year follow-up period, a total of 553 people were diagnosed with dementia, representing 0.9%.

The results show that better fitness is linked to reduced dementia risk and improved cognitive function. According to Weili Xu, Professor of Geriatric Epidemiology in the Department of Neurobiology, Care Sciences and Society, good fitness can reduce the risk of all forms of dementia by up to 35%.

– Our findings suggest that maintaining good fitness may be a strategy for preventing dementia, even among people with high genetic susceptibility, she says in a press release.

The researchers also emphasize that this is an observational study, so it is not possible to determine cause and effect. The number of dementia cases may also have been underestimated, they add, as UK Biobank participants are generally healthier than the general population.

Ultra-processed food may increase the risk of cardiovascular disease

Published 21 May 2025
– By Editorial Staff

Extra-processed foods and sugar-sweetened beverages are linked to a particularly increased risk of premature death from cardiovascular disease, according to a study from Lund University.

Ultra-processed food is food that has undergone extensive processing and contains a high proportion of added chemicals compared to “regular” processed food. This type of food is often cheap, heavily marketed and has become an increasingly important part of the Western diet in recent years.

In the study, published in Clinical Nutrition, researchers followed 27 670 participants from the Malmö Diet Cancer Study over 23 years, with funding from the Swedish Heart and Lung Foundation.

The results show that a high intake of highly processed foods and sugar-sweetened beverages is linked to an increased risk of premature death, death from cardiovascular disease and death from respiratory disease. There is an increased risk for women.

– Over-processed foods are often rich in salt, fat and added sugars, but often poor in fiber, vitamins and nutrients. Limiting intake can reduce the risk of premature death, says Emily Sonestedt, associate professor at Lund University and lead researcher of the study, in a press release.

Ultra-processed food is markedly different from what humans have been eating for thousands of years, but the long-term effects on health have yet to be studied in depth. However, links between this type of food have previously been made to depression and type 2 diabetes. At the same time, the researchers point out that more studies are needed on the subject.

–  More research is needed to better understand how ultra-processed food affects the body. In future studies, we will be able to analyze current dietary data in the Swedish population and learn more about the relationship with cardiovascular disease, says Kristina Sparreljung, Secretary General of the Swedish Heart-Lung Foundation.

Sauerkraut may help your stomach

Published 11 May 2025
– By Editorial Staff

Sauerkraut may protect the intestinal lining from inflammation, according to an American study. During fermentation, the nutritional content of cabbage changes – including an increase in levels of lactic acid, amino acids, and other beneficial substances that are formed during the breakdown and can promote gut health.

Fermentation is a natural process where microorganisms like lactic acid bacteria and yeast break down sugars in food. This often results in the conversion of sugar into lactic acid or alcohol. The process not only helps preserve the food – it also produces probiotics, meaning live bacteria that are beneficial for the gut.

Fermented foods have been eaten for thousands of years around the world. For example, eating fermented vegetables makes the nutrients in the food easier for the body to absorb, and some studies show that vitamin levels can actually increase. There are also studies that suggest fermented foods can have positive effects on health, particularly for digestion and the immune system.

Sauerkraut better than raw cabbage

Researchers at the University of California Davis in the USA tested whether the nutrients in sauerkraut could help protect intestinal cells from inflammation-related damage. The study compared sauerkraut, raw cabbage, and the brine left over after the cabbage fermentation process.

The experiments were conducted on an artificial intestinal wall exposed to inflammation by adding so-called cytokines – which are known to damage the intestinal lining. These can be activated in the gut, for example, by consuming too much ultra-processed food or too much sugar or salt.

Fermentation increases beneficial substances

The results showed that sauerkraut can protect the intestinal lining from inflammation caused by cytokines. Raw cabbage and the brine, however, did not help protect the gut. It didn’t matter whether the sauerkraut was store-bought or homemade.

Chemical analyses show that fermentation changes the nutritional profile of cabbage and increases the amount of beneficial metabolites such as lactic acid, amino acids, and plant compounds, which in turn are linked to gut health. These changes may explain why fermented foods are often associated with digestive benefits.

– Some of the metabolites we find in the sauerkraut are the same kind of metabolites we’re finding to be made by the gut microbiome, so that gives us a little more confidence that this connection we found between the metabolites in sauerkraut and good gut health makes sense, says Professor Maria Marco in a press release.

The researchers have found hundreds of different metabolites that are formed during fermentation and that they are now working to determine which ones play the biggest role in supporting long-term gut health. The next step in the research is to conduct studies in humans to see if the gut-protective metabolites found in sauerkraut can have the same positive effects when included in the daily diet, as was shown in the lab.

A little bit of sauerkraut could go a long way, she says. We should be thinking about including these fermented foods in our regular diets and not just as a side on our hot dogs.

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